diff --git a/gromacs.spec b/gromacs.spec
index de68ab4..d40bae7 100644
--- a/gromacs.spec
+++ b/gromacs.spec
@@ -8,7 +8,7 @@
 %endif
 Name:			gromacs
 Version:		2019.3
-Release:		2
+Release:		3
 Summary:		Fast, Free and Flexible Molecular Dynamics
 License:		GPLv2+ and ASL-2.0 and BSL-1.0 and MIT and LGPL-2.1
 URL:			http://www.gromacs.org
@@ -19,6 +19,7 @@ Patch0:			gromacs-dssp-path.patch
 Patch1:			gromacs-issue-2366.patch
 BuildRequires:  	gcc-c++ cmake3 >= 3.4.3 openblas-devel fftw-devel gsl-devel hwloc
 BuildRequires:  	hwloc-devel libX11-devel lmfit-devel >= 6.0 environment-modules
+BuildRequires:          chrpath
 %if %{with_opencl}
 BuildRequires:       	ocl-icd-devel 	opencl-headers
 Recommends:		gromacs-opencl = %{version}-%{release}
@@ -212,6 +213,26 @@ done
 rm ./%{_bindir}/gmx-completion.bash ./%{_libdir}/*mpi*/bin/gmx-completion-*mpi*.bash
 %ldconfig_scriptlets libs
 
+chrpath -d %{buildroot}/%{_libdir}/mpich/bin/mdrun_mpich
+chrpath -d %{buildroot}/%{_libdir}/mpich/bin/mdrun_mpich_d
+chrpath -d %{buildroot}/%{_libdir}/openmpi/bin/mdrun_openmpi
+chrpath -d %{buildroot}/%{_libdir}/openmpi/bin/mdrun_openmpi_d
+mkdir -p %{buildroot}/etc/ld.so.conf.d
+echo "%{_libdir}/mpich/lib" > %{buildroot}/etc/ld.so.conf.d/%{name}-mpich-%{_arch}.conf
+echo "%{_libdir}/openmpi/lib" > %{buildroot}/etc/ld.so.conf.d/%{name}-openmpi-%{_arch}.conf
+
+%post openmpi
+/sbin/ldconfig
+
+%post mpich
+/sbin/ldconfig
+
+%postun openmpi
+/sbin/ldconfig
+
+%postun mpich
+/sbin/ldconfig
+
 %check
 . /etc/profile.d/modules.sh
 for p in '' _d ; do
@@ -257,11 +278,16 @@ done
 
 %files openmpi
 %{_libdir}/openmpi/bin/mdrun_openmpi*
+%config(noreplace) /etc/ld.so.conf.d/%{name}-openmpi-%{_arch}.conf
 
 %files mpich
 %{_libdir}/mpich/bin/mdrun_mpich*
+%config(noreplace) /etc/ld.so.conf.d/%{name}-mpich-%{_arch}.conf
 
 %changelog
+* Mon Dec 05 2022 Ge Wang <wangge20@h-partners.com> - 2019.3-3
+- Remove runpath
+
 * Mon Nov 21 2022 wangkai <wangkai385@h-partners.com> - 2019.3-2
 - Change source url